A new human interactome map created using the yeast two-hybrid system

Although researchers have succeeded in sequencing the human genome, to expand the knowledge of functional elements within the genome, a thorough study of how human proteins operate and interact is essential. Researchers at the Dana-Farber Cancer Institute’s Center for Cancer Systems Biology have made a detailed study of genome functioning possible by creating a new human interactome map. The map is based on a systematic screen of 13,000 human proteins that revealed 14,000 pairwise interactions. The researchers have documented about 5 percent to 10 percent of all the protein-protein interactions that exist using the yeast two-hybrid system. This comprehensive study can prove to be valuable in the study of chronic diseases such as cancer.

Read more in The Scientist.